The lead essay

What we mean when we say a drug "works"

Psychedelic trials report dramatic numbers. Understanding what those numbers measure — and what they quietly leave out — is the first step to reading them honestly.

Research & science

Dr Alani Reyes, psychiatrist and clinical researcher · 9 min read

Read the essay
What we mean when we say a drug "works"

Latest essays

Thinking, not takes

Treatment-resistant
EssayDepression & anxiety

The clinical label describes what medicines have failed to do, not what a person is. That distinction changes how we read the research — and how we treat the people in it.

Dr Alani Reyes · 19 April 2026 · 6 min read

The body keeps the appointment
EssayTrauma & PTSD

Trauma is not only a memory problem. Understanding why it lives in the body helps explain why some emerging therapies work on the body's terms, not the mind's alone.

Dr Marcus Holloway · 10 April 2026 · 8 min read

Who gets to be a patient?
EssayPolicy & access

If psychedelic therapy becomes a real treatment, the next question is not whether it works but who will be able to reach it — and whether access will follow need or money.

Tomas Iwu · 2 April 2026 · 7 min read

A clinician's first session, in her words
EssayPersonal stories

A therapist describes what it was actually like to sit with a patient through a supervised dosing session — the boredom, the fear, and the part nobody had prepared her for.

As told to Priya Nandakumar · 24 March 2026 · 6 min read

Essay

People imagine the dosing session as the climax of psychedelic therapy. In practice, clinicians often describe it as the prologue. What a person does with what they saw — over weeks, sometimes months — is where a temporary experience becomes a durable change, or fails to.

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Practical guides

Start here

How to talk to your doctor about psychedelic therapy
GuideMental health

A calm, practical guide to raising the subject with a clinician — what to ask, what to expect, and how to tell credible care from a sales pitch.

Higher Place editors · 9 May 2026 · 6 min read

How to think about set and setting
GuidePsychedelic therapy

The two oldest words in this field, explained without mysticism — what they actually refer to, why clinicians take them so seriously, and how to apply the idea.

Higher Place editors · 22 April 2026 · 5 min read

How to support someone after a difficult experience
GuideHarm reduction

A harm-reduction guide for friends and family — how to be useful to someone shaken by a psychedelic experience, and how to recognise when to seek help.

Higher Place editors · 30 March 2026 · 6 min read

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